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. 2017 Jan 23;45(8):4390–4400. doi: 10.1093/nar/gkx020

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — (A) Hypomethylated genes are shorter compared to the rest of the human genes. (B) The number of CpG sites normalized by gene body length increase with the hypomethylation breadth of genes (Spearman's rho = 0.43, P < 10⁻¹⁵). Constitutively body-hypomethylated genes have the highest density of CpG sites per length. (C) Significantly overrepresented gene families (HGNC classification) at hypomethylated genes. (D) Hypomethylated genes harbor greater numbers of TSS per site than other genes. (E) Hypomethylated genes harbor greater numbers of transcription factor binding sites (TFBS) per site than other genes.