Figure 5.

Hypothyroid Animals Show a Blunted Response to Leptin Treatment. Hypothyroid Trhr1/ob dko mice (A), MMI-treated ob/ob mice (B), and euthyroid ob/ob mice were injected for 3 consecutive days with leptin. During this period as well as for additional 5 days of leptin withdrawal (W1–W5), daily food intake and bw were monitored. Changes are expressed as a percentage of baseline (day 0) weight and food intake. Whereas euthyroid ob/ob mice responded to the leptin injection with a robust decline in food intake and bw, the response was significantly less pronounced in hypothyroid Trhr1/ob dko and MMI-treated ob/ob mice. The effects of leptin treatment on bw and food intake were determined by two-way ANOVA with repeated measures. *P < .05; #P < .01; §P < .001.