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. 2017 Feb 10;45(8):4944–4957. doi: 10.1093/nar/gkx102

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 8. — Model of TIA-1 RRM23 bound to a UC-rich RNA sequence. (A) Model based on the TIA-1 RRM2/TTT structure reported herein (PDB ID: 5ITH) positioned next to the TIA-1 RRM3 structure (PDB ID: 2MJN) bound to the oligonucleotide 5΄-UUUUUACUCC-3΄ in a 5΄ to 3΄ direction. The juxtaposition of the two RRMs and the interaction between RRM3 and oligonucleotide is by structural homology to the PABP/poly-A structure (PDB ID:1CVJ). The model demonstrates that the linker region is sufficiently long to reach from the RRM2 C-terminus to the RRM3 C-terminus. (B) Topology diagram of the model highlighting the 5΄ to 3΄ directionality of the TIA-1 RRM23 interaction with target oligonucleotide.