. Author manuscript; available in PMC: 2018 May 1.

Published in final edited form as: Immunol Rev. 2017 May;277(1):61–75. doi: 10.1111/imr.12534

Table 3.

The role of caspase-1 and caspase-11 in response to viral infection in mice.

Mouse	Virus	Phenotype compared to wild-type mice
Casp1^−/−Casp11^−/−	Encephalomyocarditis virus	No difference in survival (214).
	Influenza A virus	Reduced survival (143, 144, 147), decreased IL-1β, IL-18, TNF, IL-6, KC, MIP-2 in the BALF, decreased neutrophils and monocytic dendritic cells in the BALF, diminished respiratory function (143), decreased IFN-γ producing CD4⁺ and CD8⁺ T cells, reduced nasal IgA, increased pulmonary viral titer (147). No difference in survival and body weight change in Mx1 sufficient host (148).
	Murine gamma-herpesvirus 68 (MHV68)	No difference in viral burden in the lungs (215).
	Vesicular stomatitis virus	No difference in survival (214).
	West Nile virus	Reduced survival (142).