. Author manuscript; available in PMC: 2018 May 1.

Published in final edited form as: Immunol Rev. 2017 May;277(1):61–75. doi: 10.1111/imr.12534

Table 4.

The role of caspase-1 and caspase-11 in response to fungal infection in mice.

Mouse	Fungus	Phenotype compared to wild-type mice
Casp1^−/−Casp11^−/−	Aspergillus fumigatus	Increased lung damage and hemorrhage, fungal dissemination, and reduced survival (36, 149).
	Candida albicans	Reduced survival and increased fungal burden in the kidneys, diminished T_H1/T_H17 responses (153–155).
	Paracoccidioides brasiliensis	Reduced survival, increased lung damage and hemorrhage, and fungal dissemination (156).
Casp1^−/− (also known as Casp1^Null)	Aspergillus fumigatus	Reduced survival (36).
Casp11^−/−	Aspergillus fumigatus	Reduced survival (36).