. Author manuscript; available in PMC: 2018 May 1.

Published in final edited form as: Immunol Rev. 2017 May;277(1):61–75. doi: 10.1111/imr.12534

Table 5.

The role of caspase-1 and caspase-11 in response to protozoan infection in mice.

Mouse	Protozoan	Phenotype compared to wild-type mice
Casp1^−/−Casp11^−/−	Leishmania amazonensis	Increased lesion size and parasite burden in ear, lymphnode and spleen (159).
	Leishmania major	Decreased footpad swelling, decreased pathology score and parasite burden in the footpads, decreased IL-1β and IL-18 in the footpads, decreased IL-4, IL-5 and increased IFN-γ (160), decreased infiltration of CD11b⁺ and PMN cells in the ear (216).
	Plasmodium berghei	No difference in survival when infected with sporozoites or iRBCs and no difference in parasitemia level (217, 218).
	Toxoplasma gondii	Reduced survival and decreased IL-1β and IL-18 in the serum (161).
	Trypanosoma cruzi	Reduced survival, higher parasitism in the heart, spleen and blood, higher heart injury, decreased IL-1β (162, 163), decreased production of NO from splenocytes (163).
Casp11^−/−	Toxoplasma gondii	Increased survival, decreased clinical score, altered immune responses, increased brain cysts and neuroinflammation during late stages of disease (164).