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. 2017 Jan 23;45(8):4359–4369. doi: 10.1093/nar/gkw1367

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Effect of PRMT5 inhibitor on the protein and mRNA levels of IRES-containing genes in MEFs and MCF-7 cells. (A and B) PRMT5^flox/flox MEFs were treated with DMSO or 5 μM PRMT5 inhibitor (EPZ015666, EPZ for short) for 6 days, and harvested for Western blotting for the indicated proteins (C) or RT-qPCR for the mRNA levels of the indicated genes (D). (C and D) MCF-7 cells were treated with DMSO or PRMT5 inhibitor for 6 days, and harvested for Western blotting (C) or RT-qPCR for the indicated genes (D).