Table 1. (CAG)70 Instability on YAC in Srs2 domain mutants.
Strain name | No. colonies analyzed | % Expansions | Fold over wild-type | % Contractions | Fold over wild-type |
---|---|---|---|---|---|
Wild-type | 269 | 1.1 | 1.0 | 2.6 | 1.0 |
srs2Δ | 231 | 5.6* | 5.1* | 6.5* | 2.5* |
rad51Δ | 184 | 4.9* | 4.5* | 13.6* | 5.2* |
srs2-(1-860) | 152 | 5.3* | 4.8* | 12.5* | 4.8* |
srs2-(875-902Δ) | 162 | 4.3* | 3.6* | 9.9* | 3.8* |
srs2-K41R | 201 | 5.0* | 4.5* | 9.5* | 3.7* |
srs2-(1-998) | 122 | 1.6 | 1.5 | 3.3 | 1.3 |
srs2-3KR | 157 | 1.9 | 1.7 | 5.1 | 2.0 |
srs2-K41R rad51Δ | 174 | 1.2 | 1.1 | 1.7 | 0.7 |
*P < 0.05 compared to wild-type using Fisher's Exact Test.