Figure 8.

Properties of SBS classes. (A) Shown is a heat map depicting the SBS subclass overlap with chromatin features including transcription factors, gene expression, DNA replication, histone modifications and physical and epigenetic domains. Scale for the heat map reflects the average percent overlap of SBSs within each class with genome-wide data for each feature. Statistical significance was calculated using a large sample Z-test and is indicated with an asterisk(s). (B) Proposed model of Su(Hw) function at SBS classes. DNA binding data demonstrate that binding different SBSs requires distinct ZFs and that these classes are enriched for different protein cofactors, suggesting that ZFs not engaged in DNA binding might be engaged in cofactor recruitment that might impact site-specific Su(Hw) function.