Fig. 1. Outline of the oligothymidine-initiated DNA-encoded chemistry (TiDEC) strategy. (A) Schematic presentation of a DNA-tagged compound, the coloured shapes represent partial structures of the compound; (B) the TiDEC concept to DNA-encoded libraries: (a) heterocyclic chemistry; (b) isolation of hexT conjugates; (c) DNA ligation; (C) exemplary drugs with TiDEC-accessible scaffolds. Filled black circle denotes controlled pore glass (CPG) solid support; bold bond denotes connection of the hexT-DNA to the CPG solid support; wavy bond denotes 5′-amino-PEG(4)-linker; het-cycle: heterocycle.
