Skip to main content
. 2012 May 8;26(7):1203–1212. doi: 10.1210/me.2012-1004

Fig. 2.

Fig. 2.

Impact of T2D on DNA methylation of PDX-1 in human pancreatic islets. A, A schematic representation of 3500 bp of the human PDX-1 promoter and enhancer region. The three regions analyzed for DNA methylation, representing 93 bp of the proximal promoter, 436 bp of the distal promoter, and 475 bp of the enhancer region, are visualized. DNA methylation of the proximal PDX-1 promoter (B), distal PDX-1 promoter (C), and enhancer region (D) in human pancreatic islets of nondiabetic donors (white bars) and patients with T2D (black bars). Results are expressed as mean ± sem. FDR was used to correct for multiple testing with *, Q < 0.05 nondiabetic vs. T2D islets.