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. 2017 May;187(5):963–972. doi: 10.1016/j.ajpath.2016.12.026

Figure 2.

Figure 2

Nell-1 is a downstream target of Runx2 in mouse chondrocytes. A: mRNA levels of Nell-1 in mouse chondrocytes with different genotypes of Runx2. B: Transcriptional levels of Nell-1 and Runx2 in AdRunx2-transduced Runx2+/+ mouse chondrocytes. C: mRNA levels of Runx2 in mouse chondrocytes with different genotypes of Nell-1. D: Transcriptional levels of Runx2 in Nell-1 protein stimulated Nell-1+/+ mouse chondrocytes. E: Transcriptional levels of Nell-1 and Runx2 in AdNell-1–transduced Nell-1+/+ chondrocytes. Two sample t-tests were used to compare the data from two groups. Data are expressed as means + SD of three independent experiments performed in triplicate (A–E). ∗P < 0.05 versus Runx2 mRNA expression in Runx2+/+ cells; †P < 0.05 versus Nell-1 mRNA expression in Runx2+/+ cells; ‡P < 0.05 versus Runx2 mRNA expression in AdLacz-transduced chondrocytes for 24 hours; §P < 0.05 versus Nell-1 mRNA expression in AdLacz-transduced chondrocytes for 24 hours; P < 0.05 versus Nell-1 expression in Nell-1+/+ cells; ‖P < 0.05 versus Nell-1 expression in AdLacz-transduced Nell-1+/+ chondrocytes for 24 hours. PFU, plaque-forming unit.