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. 2017 May;19(3):387–396. doi: 10.1016/j.jmoldx.2016.11.005

Figure 7.

Figure 7

Identification of the novel MYO5A-NTRK3 fusion in the spitzoid tumor sample 930. Top panel: A representative image of MYO5A-NTRK3 fusion visualization by Archer JBrowse software version 3.3.0. Middle panel: Partial sequence of the MYO5A-NTRK3 fusion transcript along with predicted amino acid sequence. The transcript is an in-frame fusion of MYO5A exon 32 to NTRK3 exon 12. Bottom panel: Schematic diagram of the predicted MYO5A-NTRK3 chimeric protein. Blue line indicates N-terminal of MYO5A; red line, C-terminal of NTRK3; purple bars, coiled-coil dimerization domains of MYO5A; orange bar, the kinase domain of NTRK3; vertical green lines in top and middle panels and the green arrow in bottom panel, the fusion point.