Figure 7.

Effects of anxiolytic and antidepressant drugs on encounter-induced hyperactivity in methamphetamine (METH)-sensitized mice. The resident chronic METH- or saline-treated mice were i.p. injected with diazepam (1 mg/kg), osemozotan (0.3 mg/kg) (A), paroxetine (10 mg/kg), fluvoxamine (30 mg/kg) (B), or vehicle 30 minutes before the encounter with the intruder. Total distance travelled in the area near the partition during the 20-minute encounters was analyzed as an index of the encounter response. Results are expressed as the mean ± SEM of 12 mice/group. *P < .05, **P < .01, ***P < .001, compared with vehicle/saline-injected saline-pretreated mice. ^†P < .05, ^††P < .01, compared with vehicle/saline-injected METH-pretreated mice.