Table 1.
Effects of 5,7-DHT on Contents of Monoamines in the Prefrontal Cortex and Striatum of Mice
| Chronic Saline | Chronic METH | |||
|---|---|---|---|---|
| Vehicle | 5,7-DHT | Vehicle | 5,7-DHT | |
| Prefrontal cortex | ||||
| 5-HT | 681 ± 62 | 75 ± 16*** | 759 ± 99 | 100 ± 39*** |
| Dopamine | 33 ± 7 | 29 ± 4 | 37 ± 2 | 28 ± 3 |
| Noradrenaline | 597 ± 38 | 490 ± 48 | 665 ± 49 | 515 ± 66 |
| Striatum | ||||
| 5-HT | 396 ± 46 | 508 ± 103 | 342 ± 56 | 415 ± 59 |
| Dopamine | 8782 ± 1412 | 10871 ± 1625 | 9927 ± 1753 | 10260 ± 1924 |
| Noradrenaline | 76 ± 7 | 95 ± 17 | 86 ± 7 | 88 ± 6 |
Results are expressed as the mean ± SEM of 11–12 mice/group. Values are expressed as ng/g tissue (wet weight). ***P < .001, compared with vehicle-treated mice.