Table 2. Common variant genes of interest.
Locus | Lead marker | Chr | GRCh37 pos. (Mb) | Associated trait(s)a | Major/minor allele | MAF | Beta sign | p-value | HWE p-value |
---|---|---|---|---|---|---|---|---|---|
ANGPTL3 | rs67461605 | 1 | 63.07 | TG | GTTAATGTG/- | 0.34 | – | 2 × 10−13 | 0.1641 |
CELSR2 | rs7528419 | 1 | 109.82 | LDL, TC | A/G | 0.23 | – | 6 × 10−17 | 0.3715 |
GCKR | rs1260326 | 2 | 27.73 | TG | C/T | 0.34 | + | 1 × 10−9 | 3.70E–05 |
MLXIPL | rs13240065 | 7 | 73.02 | TG | G/A | 0.11 | – | 2 × 10−12 | 0.1131 |
LPL | rs15285 | 8 | 19.82 | HDL | C/T | 0.32 | + | 5 × 10−24 | 0.000496 |
rs75278536 | 19.82 | TG | T/G | 0.09 | – | 1 × 10−17 | 0.1483 | ||
TRIB1 | rs28601761 | 8 | 126.5 | TC | C/G | 0.38 | – | 2 × 10−9 | 0.2015 |
rs6982502 | 125.48 | TG | T/C | 0.41 | – | 1 × 10−8 | 3.74E–09 | ||
ZNF259 | rs964184 | 11 | 116.65 | TG | C/G | 0.16 | + | 3 × 10−24 | 0.1834 |
LIPC | rs1532085 | 15 | 58.68 | HDL | G/A | 0.4 | + | 6 × 10−10 | 0.003875 |
CETP | rs247617 | 16 | 56.99 | HDL | C/A | 0.3 | + | 2 × 10−43 | 1 |
LIPG | rs4939884 | 18 | 47.17 | HDL | C/T | 0.14 | – | 2 × 10−9 | 0.2113 |
APOE | rs7412 | 19 | 45.41 | LDL, TC | C/T | 0.08 | – | 8 × 10−44 | 0.677 |
rs75627662 | 45.41 | TG | C/T | 0.18 | + | 4 × 10−13 | 0.1244 | ||
rs429358 | 45.41 | HDL | T/C | 0.14 | – | 9 × 10−10 | 6.34E–06 |
Notes.
- Chr
- chromosome
- MAF
- minor allele frequency
- TC
- total cholesterol
- TG
- triglycerides
Primary trait listed first.