Table 3. Rare variant genes of interest.
| Genea | Chr | Associated trait(s)b | Number of variantsc | p-value | q-value |
|---|---|---|---|---|---|
| PCSK9 | 1 | LDL, HDL | 22 (12) | 4 × 10−11 | 1 × 10−7 |
| LPL | 8 | HDL | 16 (15) | 3 × 10−5 | 0.0301 |
| APOC3 | 11 | TG | 2 (1) | 3 × 10−7 | 0.0018 |
| PAFAH1B2 | 11 | TG | 3 (1) | 7 × 10−5 | 0.0775 |
| CNOT2 | 12 | HDL | 2 (2) | 2 × 10−5 | 0.0283 |
| CETP | 16 | HDL | 18 (14) | 4 × 10−7 | 0.0014 |
| HNF1B | 17 | HDL | 5 (3) | 1 × 10−4 | 0.0848 |
| ANGPTL4 | 19 | TG, HDL | 14 (12) | 2 × 10−6 | 0.0049 |
| HPN-AS1 | 19 | HDL | 2 (2) | 1 × 10−4 | 0.0915 |
| SIRPD | 20 | TG | 5 (3) | 8 × 10−5 | 0.0775 |
| UBE2L3 | 22 | TG | 2 (0) | 4 × 10−5 | 0.0636 |
Notes.
- Chr
- chromosome
- TC
- total cholesterol
- TG
- triglycerides
a
Bold indicates potentially novel gene association.
b
Primary trait listed first.
c
Total number of variants (# of genotyped variants).