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. 2017 Apr 5;89(9):4808–4816. doi: 10.1021/acs.analchem.6b03510

Figure 3.

Figure 3

Bioluminescence imaging of substrates with ES-2-Fluc tumors in nude mice (a and b): (a) integrated bioluminescence emission for mice using various concentrations of luciferins (ip; 10 μM, 100 μM, 1 mM, 4 mM, and 10 mM; 100 μL); (b) representative bioluminescence images of a nude mouse implanted with ES-2-Fluc xenografts after intraperitoneal injections of various luciferins (10 μM, 0.1 mL). Comparison of dLuc, aLuc, and cybLuc in luciferase-expressing transgenic mice (c–e): (c) representative bioluminescence images of luciferase-expressing transgenic mice administered dLuc, aLuc, and cybLuc iv (1 mM, 0.1 mL); (d) total photon output from the heads of luciferase-expressing FVB transgenic mice treated with dLuc, aLuc, or cybLuc; (e) head-to-back ratio of bioluminescence. All assays were performed in triplicate and presented as the mean ± SEM; *, P < 0.05.