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Representation of the human MC2R indicating the S/T amino acid residues that have been mutated in this study A. Adapted from Ref. 63. B, Comparison of amino sequences alignment of the second intracellular of MCR 1 to 4. In yellow and blue, full or partial consensus sequences homology. Box 1 identified the T143 amino acid, box 2 amino acid frequently mutated in pathological situations, and box 3 identified the T147, which is unique to MC2R. Exo, Exoplasm; Cyto, cytoplasm.
