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Model for signal-dependent PRLr transactivation. 1) Ligand induces PRLr Y406 phosphorylation and PRLr nuclear localization; 2) PRLr-mediated recruitment of HMGN2 facilitates engagement of the PRLr/Stat5a/HMGN2 complex onto the CISH promoter; 3) the coordinated assembly of this complex promotes CISH transcriptional activation. H3K14Ac, Histone 3, lysine 9 acetylation; P, phosphorylation.
