Table 1.
IR-A substrates activated or deactivated by IGF-II (ratio M:L) or insulin (ratio H:L) identified by SILAC and previously reported as involved in insulin signaling
| Accession no. | Reference | Protein name | Experiment 1 |
Experiment 2 |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Ratio M:L | sd | Ratio H:L | sd | Ratio M:L | Significance M:L (A) | Ratio H:L | Significance H:L (A) | |||
| IPI00128358 | 58 | IR | 6.61 | 1.84 | 27.59 | 7.8 | 5.76 | 0.000 | 24.06 | 0.000 |
| IPI00379844.4 | 59 | IRS-2 | 2.20 | 0.37 | 3.24 | 0.47 | 4.70 | 0.000 | 5.47 | 0.000 |
| IPI00119627 | 59 | IRS-1 | 4.02 | 15.74 | ||||||
| IPI00117159.1 | 60 | PI3K p85 subunit β | 1.55 | 0.06 | 1.23 | 0.07 | 1.83 | 0.000 | 1.85 | 0.001 |
| IPI00229927.2 | 31 | CIP4 | 1.28 | 0.12 | 1.48 | 0.07 | 1.46 | 0.012 | 1.77 | 0.002 |
| IPI00136110.3 | 60 | PI3K p110 subunit β | 1.39 | 0.026 | 1.07 | 0.369 | ||||
| IPI00125832.1 | 61 | Caveolin-2 | 0.96 | 0.351 | 1.53 | 0.016 | ||||
| IPI00664670.4 | 32 | Filamin C | 0.82 | 0.106 | 0.65 | 0.011 | ||||
| IPI00467223 | 27 | SPIN90 | 1.38 | 0.009 | 1.25 | 0.005 | ||||
| IPI00119060 | 30 | Flotillin 2 | 1.08 | 1.42 | ||||||
sd are reported for data obtained in the first experiment and statistical significance regarding IGF-II [M:L (A)] and insulin stimulation [H:L (A)] for data obtained in the second experiment, as detailed in Materials and Methods.