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. 2011 Apr 28;25(7):1100–1110. doi: 10.1210/me.2010-0436

Fig. 6.

Fig. 6.

GR first exon-dependent translational efficiency. Results from in vitro translation (panel A) and transfection of AtT-20 cells (panel B) with exon 1-luciferase constructs. Luciferase activity of exonic constructs were normalized to respective mRNA levels and expressed relative to control vector. Panel C, Effect of predicted deleterious mutations on GR first exon-dependent translational efficiency. Luciferase activity of exonic constructs transfected into AtT-20 cells was normalized to respective mRNA levels and expressed relative to corresponding wild-type exon 1. Data represent three independent experiments. Error bars represent sem; *, P < 0.05; §, P <0.001; n/a, not applicable; ND, not detectable; wt, wild type; mut, mutant; Ctrl, control.