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. 2010 Nov;24(11):2139–2151. doi: 10.1210/me.2010-0134

Fig. 2.

Fig. 2.

Summation of the trans-activating effects of PPARγ and cAMP on renin promoter. A, Time course of the effect of rosiglitazone (500 nm), PACAP (300 nm), or the combination of both on the activity of CRE-hRenMin promoter construct. B, Effect of rosiglitazone (500 nm), PACAP (300 nm), or the combination of both on the activity of a CRE-driven reporter construct (pCRE-Luc). C, Effect of rosiglitazone (500 nm), PACAP (300 nm), or the combination of both on the activity of hRenMin promoter construct that lacks functional CRE. Calu-6 cells were incubated for 16 h with the indicated substances. Control cells remained untreated. RLA, Relative luciferase activity; Rosi, rosiglitazone. The data shown are means ± sem; *, P < 0.05.