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. 2010 Oct;24(10):1988–1997. doi: 10.1210/me.2010-0115

Fig. 6.

Fig. 6.

Effect of islet PFK-2/FBPase-2 on glucose-induced insulin secretion. Insulin-secreting MIN6 cells were transfected with EYFP (white bars), EYFP-PFK-2/FBPase-2 (black bars), or EYFP-PFK-2/FBPase-2-Mut (gray bars) and cultured for 48 h. Cells were starved for 1 h and thereafter stimulated for 1 h with 3, 10, or 25 mmol/liter glucose, respectively. Insulin secretion is shown as insulin secreted per cellular insulin content and protein. Data are expressed as means ± sem of four individual experiments. *, P < 0.05 compared with negative control; #, P < 0.05; ##, P < 0.01 compared with EYFP-PFK-2/FBPase-2-Mut stimulated with the same glucose concentration (ANOVA/Bonferroni’s test).