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Pituitary phenotype of 8-month-old mice of the indicated genotypes
| Phenotype | Wt | Tg-PCE | p27 Kip1−/− | Tg-PCE;p27 Kip1−/− |
|---|---|---|---|---|
| Normal | 100% (12/12) | 88% (7/8) | 21% (3/14) | — |
| IL hyperplasia | — | — | 7% (1/14) | — |
| IL adenoma | — | — | 72% (10/14) | 100% (10/10) |
| AL hyperplasia | — | 12% (1/8) | — | — |
| AL adenoma | — | — | 7% (1/14) | 40% (4/10) |
| IL and AL adenoma | — | — | 7% (1/14) | 40% (4/10) |
The percentage and numbers of observed phenotypes are indicated over the total number of mice in each group. —, Not observed.
