Table 1.
Transcription factors located close to differentially methylated regions in OMA, as compared to EE
| Gene symbol | Gene name | Methylation status | Induction ratio | Ratio OMA/EE | Consistent methylation/ expression |
|---|---|---|---|---|---|
| C20orf20 | Chromosome 20 open reading frame 20 | Hypomethylated | 1.66 | 0.545 | |
| MAFB | v-maf Musculoaponeurotic fibrosarcoma oncogene homolog b (avian) | Hypomethylated | 1.21 | 0.584 | |
| E2F3 | e2f Transcription factor 3 | Hypomethylated | 0.47 | 0.593 | No |
| ZNF79 | Zinc finger protein 79 (pt7) | Hypomethylated | 1.15 | 0.611 | |
| RXRA | Retinoid x receptor, α | Hypomethylated | 2.38 | 0.648 | Yes |
| RING1 | Ring finger protein 1 | Hypermethylated | 1.04 | 1.511 | |
| RXRB | Retinoid x receptor, β | Hypermethylated | 2.44 | 1.511 | No |
| HOXD10 | Homeobox d10 | Hypermethylated | 0.27 | 1.525 | Yes |
| HOXD11 | Homeobox d11 | Hypermethylated | 0.43 | 1.525 | Yes |
| BBX | Bobby sox homolog (Drosophila) | Hypermethylated | 0.60 | 1.586 | |
| TFDP3 | Transcription factor dp family, member 3 | Hypermethylated | 7.45 | 1.641 | No |
| PCGF3 | Polycomb group ring finger 3 | Hypermethylated | 0.49 | 1.649 | Yes |
| MAFF | v-maf Musculoaponeurotic fibrosarcoma oncogene homolog f (avian) | Hypermethylated | 1.10 | 1.829 | |
| ZNF707 | Zinc finger protein 707 | Hypermethylated | 0.94 | 1.884 | |
| HSFX1 | lw-1 | Hypermethylated | 1.83 | 1.907 | |
| ZNF12 | Zinc finger protein 12 | Hypermethylated | 1.09 | 2.009 | |
| TCFL5 | Transcription factor-like 5 (basic helix-loop-helix) | Hypermethylated | 1.52 | 2.107 | |
| ZNF22 | Zinc finger protein 22 (kox 15) | Hypermethylated | 0.79 | 2.188 | |
| ZNF426 | Zinc finger protein 426 | Hypermethylated | 2.25 | 2.418 | No |
| CBFA2T3 | Core-binding factor, runt domain, α subunit 2; translocated to, 3 | Hypermethylated | 1.14 | 2.689 |
This gene list results from the DAVID gene functional clustering for the 161 regions found differentially methylated in OMA. Induction ratio denotes the gene expression level in OMA vs. EE; when above 2.0, the gene is up-regulated; when below 0.5, the gene is down-regulated. Ratio OMA/EE denotes the promoter methylation level in OMA vs. EE; when above 1.5, the promoter is hypermethylated: when below 0.66, the promoter is hypomethylated. The eight genes, the expression of which is consistent with promoter methylation status, are marked in bold. Expressional data result from Borgheseet al. (10 ).