Table 2.
Genomic regions significantly and consistently hypermethylated or hypomethylated in SUP, OMA, and DIE, as compared with EE
| Chromosome | No. active region | Start | Length | Ratio SUP/EE | Ratio OMA/EE | Ratio DIE/EE | Gene symbol | Gene name |
|---|---|---|---|---|---|---|---|---|
| 2 | 1466 | 242661047 | 1477 | 0.52 | 0.29 | 0.59 | FLJ38379 | Hypothetical protein FLJ38379 |
| 2 | 1467 | 242662876 | 1138 | 0.62 | 0.40 | 0.39 | FLJ38379 | Hypothetical protein FLJ38379 |
| 2 | 1470 | 131249876 | 565 | 0.43 | 0.36 | 0.41 | DEFB125 | Defensin, β 125 |
| 3 | 1728 | 122953778 | 587 | 0.60 | 0.59 | 0.60 | GOLGB1 | Golgin B1, Golgi integral membrane protein |
| 5 | 1896 | 763481 | 1315 | 0.37 | 0.65 | 0.60 | ||
| 5 | 1911 | 1669770 | 393 | 0.55 | 0.35 | 0.52 | ||
| 5 | 1999 | 170219671 | 206 | 0.44 | 0.62 | 0.59 | ||
| 6 | 2091 | 138477515 | 243 | 0.66 | 0.60 | 0.57 | PERP | TP53 apoptosis effector |
| 7 | 2186 | 56207807 | 8821 | 1.54 | 1.61 | 1.91 | ||
| 7 | 2263 | 156232815 | 1524 | 3.10 | 3.06 | 2.16 | NOM1 | Nucleolar protein with MIF4G domain 1 |
| 9 | 2396 | 17261249 | 762 | 0.64 | 0.65 | 0.60 | CNTLN | Centlein, centrosomal protein |
| 10 | 224 | 44815659 | 252 | 2.05 | 2.19 | 1.82 | RASSF4 | ras Association (RalGDS/AF-6) domain family member 4 |
| 10 | 224 | 44815659 | 252 | 2.05 | 2.19 | 1.82 | C10orf25 | Chromosome 10 open reading frame 25 |
| 10 | 224 | 44815659 | 252 | 2.05 | 2.19 | 1.82 | ZNF22 | Zinc finger protein 22 (KOX 15) |
| 11 | 310 | 520194 | 1229 | 1.69 | 2.58 | 1.83 | HRAS | v-Ha-ras Harvey rat sarcoma viral oncogene homolog |
| 11 | 310 | 520194 | 1229 | 1.69 | 2.58 | 1.83 | LRRC56 | Leucine-rich repeat containing 56 |
| 13 | 558 | 112809520 | 1027 | 1.83 | 2.47 | 2.03 | F7 | Coagulation factor VII (serum prothrombin conversion accelerator) |
| 13 | 561 | 113114806 | 556 | 2.30 | 2.44 | 1.52 | DKFZp451A211 | DKFZp451A211 protein |
| 13 | 561 | 113114806 | 556 | 2.30 | 2.44 | 1.52 | ADPRHL1 | ADP-ribosylhydrolase like 1 |
| 16 | 735 | 1250431 | 492 | 1.57 | 1.59 | 1.67 | TPSD1 | tryptase δ 1 |
| 16 | 815 | 31142886 | 513 | 1.63 | 1.71 | 1.64 | PYDC1 | PYD (pyrin domain) containing 1 |
| 17 | 986 | 54115047 | 229 | 0.51 | 0.56 | 0.66 | TEX14 | Testis expressed 14 |
| 17 | 986 | 54115047 | 229 | 0.51 | 0.56 | 0.66 | RAD51C | RAD51 homolog C (S. cerevisiae) |
| 19 | 1136 | 617852 | 1086 | 2.38 | 1.85 | 1.58 | RNF126 | Ring finger protein 126 |
| 19 | 1136 | 617852 | 1086 | 2.38 | 1.85 | 1.58 | FSTL3 | Follistatin-like 3 (secreted glycoprotein) |
| X | 2538 | 37114623 | 597 | 0.53 | 0.55 | 0.58 | FTHL19 | Ferritin, heavy polypeptide-like 19 |
Regions with a ratio above 1.50 or below 0.66 were taken into consideration.