Table 3.

List of active regions and nearby genes, which share alterations both in methylation and expressional patterns

Gene symbol	Gene name	Methylation status	Induction ratio	No. active region	Chromosome	Ratio OMA/EE	Ratio SUP/EE	Ratio DIE/EE
PYDC1	PYD (pyrin domain) containing 1	Hypermethylated	2.52	815	16	1.71	1.63	1.64
FSTL3	Follistatin-like 3 (secreted glycoprotein)	Hypermethylated	2.07	1136	19	1.85	2.38	1.58
FLJ38379	Hypothetical protein FLJ38379	Hypomethylated	0.41	1466	2	0.29	0.52	0.59
FLJ38379	Hypothetical protein FLJ38379	Hypomethylated	0.41	1467	2	0.40	0.62	0.39
PERP	TP53 apoptosis effector	Hypomethylated	0.08	2091	6	0.60	0.66	0.57
EDARADD	EDAR-associated death domain	Hypermethylated	2.32	178	1	1.68	NS	1.53
LOC440993	Hypothetical gene supported by AK128346	Hypermethylated	2.18	1773	3	2.24	NS	1.50
ADAP1	ArfGAP with dual PH domains 1	Hypermethylated	0.37	2127	7	1.55	NS	1.55
JAKMIP3	Janus kinase and microtubule interacting protein 3	Hypermethylated	3.65	275	10	1.81	NS	1.50
MPP3	Membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	Hypermethylated	2.12	963	17	1.91	NS	1.77
SLC16A3	Solute carrier family 16, member 3 (monocarboxylic acid transporter 4)	Hypermethylated	0.42	1043	17	1.60	NS	1.53
TFDP3	Transcription factor Dp family, member 3	Hypermethylated	3.08	2614	X	1.64	NS	1.53
SLC16A3	Solute carrier family 16, member 3 (monocarboxylic acid transporter 4)	Hypermethylated	0.42	1042	17	1.51	1.51	NS
FAIM3	Fas apoptotic inhibitory molecule 3	Hypomethylated	4.44	148	1	0.65	0.64	NS
PIGR	polymeric immunoglobulin receptor	Hypomethylated	0.24	148	1	0.65	0.64	NS
EPCAM	Epithelial cell adhesion molecule	Hypomethylated	0.11	1357	2	0.62	0.64	NS
PRKCQ	Protein kinase C, θ	Hypomethylated	0.25	200	10	0.62	0.51	NS
PLD2	Phospholipase D2	Hypomethylated	2.01	910	17	0.56	0.57	NS
CBS	Cystathionine-β-synthase	Hypomethylated	4.07	1571	21	0.51	0.58	NS
TNNI3K	TNNI3-interacting kinase	Hypermethylated	3.17	95	1	1.77	NS	NS
(Continued)