Table 2. Regression Analysis of Ag85A IFN-γ response as measured by ELISPOT on day 7 and Area Under the Curve analysis for days 0 to 28.
| Factor | Level | Estimate (Bootstrap 95% | P-value |
|---|---|---|---|
| C.I) | |||
| Ag85A at day 7 | |||
| Constant | 1272.3 (-2066.5; 4611.0) | - | |
| Age | Per one year | -76.4 (-303.9; 151.2) | 0.51 |
| increase | |||
| Sex | Male | 0 (Ref) | 0.41 |
| Female | 232.4 (-318.8; 783.1) | ||
| School | Busabala | 0 (Ref) | 0.12 |
| Officers’ children | -225.6 (-1432.9; 981.8) | ||
| Kigo-Lunya | 35.2 (-1055.7; 1126.1) | ||
| Bulega | 471.9 (-346.0; 1289.7) | ||
| Bugiri | 563.3 (-750.2; 1876.9) | ||
| Hookworm stool | Negative | 0 (Ref) | 0.67 |
| PCR | Positive | 216.0 (-735.8; 1167.8) | |
| Helminth Group | No helminth | 0 (Ref) | 0.65 |
| S. mansoni only | 185.1 (-607.3; 977.4) | ||
| AUC for Ag85A (day 0-day 28) | |||
| Constant | 14 692 (-90 254; 119 639) | - | |
| Age | Per one year | -821 (-8 565; 6 923) | 0.84 |
| increase | |||
| Sex | Male | 0 (Ref) | 0.68 |
| Female | 3 018 (-11 301; 17 336) | ||
| School | Busabala | 0 (Ref) | 0.32 |
| Officers’ children | 43 (-27 250; 27 336) | ||
| Kigo-Lunya | 4 839 (-19 193; 28 872) | ||
| Bulega | 7 219 (-12 637; 27 075) | ||
| Bugiri | 20 711 (-6 649; 48 071) | ||
| Hookworm stool | Negative | 0 (Ref) | 0.92 |
| PCR | Positive | -1 118 (-24 189; 21 954) | |
| Helminth Group | No helminth | 0 (Ref) | 0.56 |
| S. mansoni only | 5 673 (-13 511; 24 856) | ||
Abbreviations: Ag85A, Antigen 85A; IFN-γ, interferon gamma; C.I., confidence interval; PCR, polymerase chain reaction; Sm, Schistosoma mansoni; Ref, reference; AUC, Area under the curve