Table 1.
Echocardiographic measurement
| Parameter | WT | ARKO | ||||
|---|---|---|---|---|---|---|
| Vehicle | Dox | Vehicle | Dox | |||
| LVDd (mm) | 3.98 ± 0.09 | 3.78 ± 0.10 | 3.21 ± 0.0424 | 3.72 ± 0.095 | ||
| LVDs (mm) | 2.44 ± 0.06 | 2.46 ± 0.08 | 1.91 ± 0.0424 | 2.66 ± 0.09††5 | ||
| IVS (mm) | 0.80 ± 0.02 | 0.81 ± 0.03 | 0.62 ± 0.0224 | 0.58 ± 0.0224 | ||
| PW (mm) | 0.84 ± 0.03 | 0.80 ± 0.03 | 0.68 ± 0.0223 | 0.64 ± 0.0224 | ||
| FS (%) | 39.4 ± 0.9 | 35.7 ± 0.71 | 40.7 ± 0.84 | 28.1 ± 1.2245 | ||
LVDd, Left ventricular end-diastolic dimension; LVDs, left ventricular end-systolic dimension; IVS, interventricular septal thickness; PW, posterior wall. Values are means ± sem, each group n = 20.
1
P < 0.05 vs. WT-vehicle.
2
P < 0.01 vs. WT-vehicle.
3
P < 0.05 vs. WT-Dox.
4
P < 0.01 vs. WT-Dox.
5
P < 0.01 vs. KO-vehicle.