Table 1. Weighted sample characteristics, pain and MRI features by cycle.
| MRI feature | Baseline (Weighted N = 122.0) | 1st Follow-up (Weighted N = 108.6) | 2nd Follow-up (Weighted N = 122.0) |
|---|---|---|---|
| Female, n (%) | 68.0 (55.7) | 59.9 (55.1) | 68.0 (55.7) |
| Age | 55.5 (9.1) | 59.0 (8.8) | 63.0 (9.0) |
| BMI | 26.1 (4.0) | 26.1 (4.0) | 26.3 (4.4) |
| KL grade, n (%) | |||
| 0 | 49.7 (40.8) | 26.8 (24.6) | 36.7 (30.1) |
| 1 | 24.0 (19.7) | 23.7 (21.8) | 20.6 (16.9) |
| 2 | 27.4 (22.5) | 28.2 (26.0) | 21.6 (17.7) |
| 3 | 13.8 (11.3) | 13.4 (12.3) | 21.0 (17.2) |
| 4 | 7.1 (5.8) | 16.6 (15.3) | 19.5 (16.0) |
| Missing | 0.0 (0.0) | 0.0 (0.0) | 2.6 (2.1) |
| WOMAC pain | 19.1 (17.3) | 15.0 (15.9) | 19.6 (20.5) |
| Osteophytes (sum/8)1 | 0.93 (0.47) | 1.00 (0.48) | 1.17 (0.57) |
| Cartilage (sum/6)1 | 1.74 (0.59) | 1.84 (0.64) | 2.04 (0.76) |
| Subchondral sclerosis (sum/6)1 | 0.08 (0.16) | 0.12 (0.21) | 0.18 (0.31) |
| Subchondral cysts (sum/6)1 | 0.06 (0.15) | 0.08 (0.16) | 0.13 (0.19) |
| BML (sum/6)1 | 0.27 (0.32) | 0.29 (0.36) | 0.47 (0.48) |
| Meniscus (sum/6)1 | 0.48 (0.64) | 0.56 (0.71) | 0.65 (0.73) |
| Effusion/synovitis ≥2, n (%) | 36.1 (29.6) | 51.3 (47.2) | 56.0 (45.9) |
Mean (SD) or otherwise indicated
1 Average grade across regions