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. 2017 Mar 20;52(6):324–333. doi: 10.1097/RLI.0000000000000344

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Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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A, Macroscopic skin appearance and (B) an overview of the skin tissue and (C and D) enlarged H&E skin sections of animals administered saline, gadodiamide, gadopentetate dimeglumine, gadoteridol, and gadobutrol. Representative H&E-stained FFPE sections of animals, each injected with 20 injections at a dose of 2.5 mmol Gd/kg body weight at 8 weeks after the last injection. All animals in the gadodiamide group showed fibrosis and mononuclear cell infiltration and an increase in dermal cellularity compared with the saline group and all other investigated groups.