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. 2017 Mar 20;52(6):324–333. doi: 10.1097/RLI.0000000000000344

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Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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A, Eight weeks after the last injection (20 × 2.5 mmol Gd/kg body weight), high Gd concentrations were measured for the linear agents gadodiamide and gadopentetate dimeglumine in the skin and bone. B, The average concentration (mean ± SD) of residual Gd in the brain was approximately 100-fold lower compared with the skin in gadodiamide-injected rats and approximately 15-fold higher for linear than for macrocyclic GBCAs. Low Gd concentrations were measurable when both classes of GBCAs were used.