Table 3. Graded histopathologic changes in individual animals.
Strain | C3H/HeJ Strain | C57BL/6 | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Treatment | Control | WY-14,643 | Control | WY-14,643 | ||||||||||||
Mouse ID# | 31 | 32 | 33 | 34 | 51 | 52 | 53 | 55 | 37 | 38 | 39 | 40 | 56 | 57 | 59 | 60 |
Hypertrophy, hepatocyte | 0 | 0 | 0 | 0 | 4 | 4 | 4 | 4 | 0 | 0 | 0 | 0 | 4 | 4 | 4 | 4 |
Mitotic figures, Hepatocyte | 0 | 0 | 0 | 0 | 2 | 2 | 2 | 2 | 0 | 0 | 0 | 0 | 2 | 2 | 2 | 2 |
Cellular infiltrate, sinusoidal | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 1 |