Table 1. Samples and results of deep sequencing in Cases 1 and 2.

	Date	Type of samples	CD4 (/μl)	VL (/ml)	Mean read number	Mean % of X4 virus
Case 1	Oct 2003	serum	475	7800	25327	0
	Apr 2005	PBMC	509	16000	2735	0
	Jan 2006	plasma	551	12000	5786	0
	Apr 2006	PBMC	597	18000	36757	0
	Jul 2006	plasma	619	18000	17582	0.9
	Oct 2006	PBMC	429	42000	6661	3.8
	Jan 2007	PBMC	382	36000	6290	23.3
		serum			6533	4.3
	Apr 2007	serum	257	69000	2644	8.6
	Jul 2007	serum	171	84000	8751	0.7
	Nov 2007	PBMC	88	58000	10816	17.4
Case 2	Sep 1997	serum	536	1600	4011	0
	Oct 2001	serum	313	230	2516	0
	Jan 2005	serum	223	600	3476	0
	Jan 2007	serum	285	300	1385*	0*
	Jan 2008	serum	218	270	3231*	0*
	Jan 2009	plasma	221	530	3118	90.5
	Nov 2011	serum	44	11000	4813	16.0

* PCR was successful only once, thus these results represent one deep sequencing only.

VL: viral load.