Table 1. Distribution of the ALDH2 rs671 polymorphism, and drinking habit in the participants in the case-control study.
| Cases, n(%) |
Controls, n(%) | Crude OR (95%CI) | P | Adjusted OR (95%CI) a | P | PHWE | ||
|---|---|---|---|---|---|---|---|---|
| rs671 | ||||||||
| Overall | GG | 586(53.7) | 606 (49.1) | 1.00 | 1.00 | 0.218 | ||
| AG | 440(40.3) | 531(43.0) | 0.86(0.72–1.02) | 0.075 | 0.85(0.71–1.02) | 0.084 | ||
| AA | 65(6.0) | 98(7.9) | 0.69(0.49–0.96) | 0.027 | 0.67(0.46–0.96) | 0.028 | ||
| AA/AG | 505(46.3) | 629 (50.9) | 0.83(0.71–0.98) | 0.025 | 0.82(0.69–0.98) | 0.029 | ||
| AG/GG | 1026(94.0) | 1137(92.1) | 1.00 | 1.00 | ||||
| AA | 65(6.0) | 98(7.9) | 0.74(0.53–1.02) | 0.063 | 0.72(0.5–1.02) | 0.064 | ||
| G | 1612(73.9) | 1743(70.6) | 1.00 | <0.001 | ||||
| A | 570(26.1) | 727(29.4) | 0.85(0.77–0.93) | |||||
| Male | GG | 267(52.8) | 264(46.8) | 1.00 | 1.00 | 0.398 | ||
| AG | 206(40.7) | 250(44.3) | 0.81(0.63–1.05) | 0.109 | 0.79(0.6–1.03) | 0.081 | ||
| AA | 33(6.5) | 50(8.9) | 0.65(0.41–1.05) | 0.076 | 0.61(0.37–1.03) | 0.065 | ||
| AA/AG | 239(47.2) | 300(53.2) | 0.79(0.62–1) | 0.052 | 0.76(0.58–0.98) | 0.036 | ||
| AG/GG | 473(93.5) | 514(91.1) | 1.00 | 1.00 | ||||
| AA | 33(6.5) | 50(8.9) | 0.72(0.45–1.13) | 0.154 | 0.69(0.41–1.13) | 0.142 | ||
| G | 740(73.1) | 778(69.0) | 1.00 | |||||
| A | 272(26.9) | 350(31.0) | 0.82(0.68–0.99) | 0.035 | ||||
| Female | GG | 319(54.5) | 342(51.0) | 1.00 | 1.00 | 0.344 | ||
| AG | 234(40.0) | 281(41.9) | 0.89(0.71–1.12) | 0.336 | 0.92(0.72–1.18) | 0.497 | ||
| AA | 32(5.5) | 48(7.2) | 0.71(0.45–1.15) | 0.164 | 0.72(0.43–1.21) | 0.214 | ||
| AA/AG | 266(45.5) | 329(49.0) | 0.87(0.69–1.08) | 0.207 | 0.89(0.7–1.13) | 0.337 | ||
| AG/GG | 553(94.5) | 623(92.8) | 1.00 | 1.00 | ||||
| AA | 32(5.5) | 48(7.2) | 0.75(0.47–1.19) | 0.224 | 0.75(0.46–1.24) | 0.262 | ||
| G | 872 (74.5) | 965(71.9) | 1.00 | |||||
| A | 298(25.5) | 377(28.1) | 0.88(0.73–1.05) | 0.139 | ||||
| Drinking | ||||||||
| Overall | No | 840(68.0) | 755(69.1) | 1.00 | 1.00 | |||
| Yes | 395(32.0) | 338(30.9) | 0.952(0.80–1.14) | 0.583 | 1.109(0.89–1.38) | 0.358 | ||
| Male | No | 247(43.7) | 231(45.5) | 1.00 | 1.00 | |||
| Yes | 318(56.3) | 277(54.5) | 0.931(0.73–1.19) | 0.563 | 1.250 (0.95–1.64) | 0.108 | ||
| Female | No | 593(88.5) | 524(89.6) | 1.00 | 1.00 | |||
| Yes | 77(11.5) | 61(10.4) | 0.897(0.63–1.28) | 0.547 | 0.868(0.59–1.28) | 0.472 | ||
a Adjusted for age, sex, BMI and smoking