Table 2. Univariate and multivariate analysis of risk factors associated with overall survival.
| Variables | Univariate HR (95% CI) |
Univariate P-value |
Multivariate HR (95% CI) |
Multivariate P-value |
|---|---|---|---|---|
| Age, y | 1.00 (0.97–1.02)a | 0.81 | ||
| Sex (men vs. women) | 1.10 (0.49–2.46) | 0.81 | ||
| Location (others vs. extremity) | 2.59 (0.35–19.21) | 0.35 | ||
| Solar exposure (intermittent/chronic vs. no) | 1.00 (0.37–2.7) | 0.99 | ||
| Lymph node status (present vs. absent) | 5.47 (2.37–12.65) | <0.001* | 3.85 (1.49–9.93) | 0.005* |
| Ulcer (present vs. absent) | 4.67 (2.04–10.72) | <0.001* | 4.12 (1.67–10.16) | 0.002* |
| Thickness, mm | 1.02 (0.97–1.08)a | 0.42 | ||
| Mitosis/mm2 | 1.06 (1.01–1.11)a | 0.03* | 1.00 (0.93–1.07)a | 0.99 |
| Subtype (others vs. NM) | 0.27 (0.06–1.18) | 0.08 | ||
| Associated nevus (present vs. absent) | 0.18 (0.02–1.34) | 0.09 | 0.25 (0.03–1.95) | 0.19 |
Abbreviations: CI, confidence intervals; HR, hazard ratio; NM, nodular melanoma.
aHazard ratio corresponds to a 1-year increase in age, 1-mm increase in thickness and 1- mitosis increase per mm2