Table 3. Clinical and histologic characteristics in acral lentigious melanomas.

Characteristic	Total	De novo	Nevus-associated	P-valuea
Age (years)
<65	25	24 (96.0%)	1 (4.0%)	0.41
≥65	48	42 (87.5%)	6 (12.5%)
Sex
Female	34	30 (88.2%)	4 (11.8%)	0.70
Male	39	36 (92.3%)	3 (7.7%)
Thickness of invasive melanomas (n = 63), mm				0.43
≤ 1.0	11	9 (81.8%)	2 (18.2%)
1.01–2.0	19	17 (89.5%)	2 (10.5%)
2.01–4.0	18	16 (88.9%)	2 (11.1%)
>4.0	15	15 (100%)	0 (0.0%)
Mitosis/mm2
<1	19	17 (89.5%)	2 (10.5%)
1–5	43	40 (93.0%)	3 (7.0%)	0.40
≥6	11	9 (81.8%)	2 (18.2%)
Ulceration
Absent	50	46 (92.0%)	4 (8.0%)	0.67
Present	23	20 (87.0%)	3 (13.0%)
Sentinel lymph node status
Negative	61	54 (88.5%)	7 (11.5%)	0.59
Positive	12	12 (100%)	0 (0.0%)
AJCC Stage
Tis	10	9 (90.0%)	1 (10.0%)
Stage 1–2	49	43 (87.8%)	6 (12.2%)	0.49
Stage 3–4	14	14 (100%)	0 (0.0%)
Lymphovascular invasion
Absent	66	59 (89.4%)	7 (10.6%)	1.00
Present	7	7 (100%)	0 (0.0%)
Desmoplastic component
Absent	66	59 (89.4%)	7 (10.6%)	1.00
Present	7	7 (100%)	0 (0.0%)
Neurotropism
Absent	60	53 (88.3%)	7 (11.7%)	0.34
Present	13	13 (100%)	0 (0.0%)
Regression
Absent	64	57 (89.1%)	7 (10.9%)	0.59
Present	9	9 (100%)	0 (0.0%)
Infiltrating lymphocyte
Absent	12	12 (100%)	0 (0%)
Non-brisk	57	50 (87.7%)	7 (12.3%)	0.56
Brisk	4	4 (100%)	0 (0%)
Predominant cell typeb
Epithelioid	23	18 (78.3%)	5 (21.7%)
Spindle	5	5 (100%)	0 (0%)	0.09
Mixed	32	31 (96.9%)	1 (3.1%)

AJCC, American Joint Committee on Cancer; NM, nodular melanoma; SSM, superficial spreading melanoma

^a Comparison by Fisher’s exact test.

^b Thirteen cases with unknown predominant cell type excluded for this stratum.