Figure 3.

Western blots demonstrating that the GR cell line, HCC827/GR-8-1, demonstrated markedly increased levels of vimentin, and that treatment with gefitinib led to the complete absence of β-catenin protein expression.

Notes: However, after treatment with a combination of GW3965 and gefitinib, the expression level of vimentin was significantly reduced and that of β-catenin clearly increased. GW3965 did not affect the expression of E-cadherin. No changes in EGFR protein levels were observed in cultured cells exposed to 5 µmol/mL gefitinib.

Abbreviations: EGFR, epidermal growth factor receptor; GR, gefitinib-resistant.