Table 6.
Predictors of MS-related hospital visits, ER visits, and outpatient visits in patients with MS treated with DMTs (n=12,431)
| Variables | Hospital visitsa | P-value | ER visitsa | P-value | Outpatient visitsb | P-value |
|---|---|---|---|---|---|---|
| Sex | ||||||
| Female | Reference | Reference | Reference | |||
| Male | 0.939 (0.799–1.104) | 0.4478 | 0.826 (0.737–0.925) | 0.0009 | –0.019 (0.152) | 0.901 |
| Age at index DMT | 1.029 (1.022–1.036) | <0.0001 | 0.992 (0.988–0.997) | 0.0009 | 0.01 (0.006) | 0.110 |
| CCI score | ||||||
| 0 | Reference | Reference | Reference | |||
| 1 | 1.239 (1.053–1.457) | 0.0097 | 1.457 (1.304–1.628) | <0.0001 | 1.035 (0.148) | <0.0001 |
| 2 | 1.767 (1.421–2.198) | <0.0001 | 1.81 (1.545–2.12) | <0.0001 | 0.94 (0.229) | <0.0001 |
| ≥3 | 1.678 (1.374–2.048) | <0.0001 | 2.052 (1.782–2.364) | <0.0001 | 1.724 (0.206) | <0.0001 |
| PDC group | ||||||
| <0.8 | Reference | Reference | Reference | |||
| ≥0.8 | 0.478 (0.417–0.547) | <0.0001 | 0.62 (0.565–0.681) | <0.0001 | –0.712 (0.132) | <0.0001 |
Notes:
a
Values represent point estimates for the OR (95% CI) generated by logistic regression;
b
values represent coefficient estimates (SE) generated by ordinal least-squares regression.
Abbreviations: MS, multiple sclerosis; ER, emergency room; DMTs, disease-modifying therapies; CCI, Charlson Comorbidity Index; PDC, proportion of days covered; OR, odds ratio; CI, confidence interval; SE, standard error.