Table 2. Associations of SLC5A2 SNPs with serum glucagon concentrations during the 5-point OGTT.
| Geno-type | N | Glucagon 0 min (pmol/L) |
Glucagon 30 min (pmol/L) |
Glucagon 60 min (pmol/L) |
Glucagon 90 min (pmol/L) |
Glucagon 120 min (pmol/L) |
Glucagon AUCi 0–120 min (pmol/L) |
Glucagon decrease 0–120 min (fold-change) |
|
|---|---|---|---|---|---|---|---|---|---|
| rs9924771 | GG | 181 | 65.6 ± 25.0 | 62.4 ± 21.9 | 56.5 ± 21.2 | 53.5 ± 18.4 | 53.3 ± 19.3 | 21.4 ± 25.2 | 0.86 ± 0.27 |
| GA | 157 | 67.5 ± 25.0 | 61.8 ± 23.0 | 56.3 ± 21.1 | 53.7 ± 20.0 | 54.1 ± 18.9 | 24.6 ± 24.4 | 0.84 ± 0.25 | |
| AA | 37 | 63.4 ± 20.4 | 63.5 ± 19.9 | 56.2 ± 20.0 | 54.7 ± 16.3 | 53.4 ± 14.9 | 16.7 ± 18.2 | 0.89 ± 0.24 | |
| padd / pdom | - | - | 0.7 / 0.9 | 0.7 / 0.6 | 0.9 / 1.0 | 0.9 / 1.0 | 0.7 / 0.6 | 0.5 / 0.9 | 0.3 / 0.6 |
| rs3116150 | GG | 211 | 66.0 ± 24.0 | 61.9 ± 21.0 | 56.1 ± 20.9 | 54.0 ± 19.1 | 53.8 ± 18.4 | 22.3 ± 25.5 | 0.86 ± 0.27 |
| GA | 141 | 67.3 ± 25.8 | 63.5 ± 24.1 | 56.8 ± 21.3 | 53.9 ± 18.6 | 53.6 ± 18.8 | 22.9 ± 22.8 | 0.83 ± 0.23 | |
| AA | 23 | 60.6 ± 22.7 | 57.7 ± 20.0 | 55.5 ± 20.7 | 49.8 ± 18.2 | 52.6 ± 21.0 | 18.7 ± 23.8 | 0.92 ± 0.30 | |
| padd / pdom | - | - | 0.8 / 0.8 | 0.8 / 0.9 | 0.7 / 0.7 | 0.5 / 0.8 | 0.7 / 0.8 | 1.0 / 0.8 | 0.9 / 0.5 |
| rs3813008 | GG | 274 | 65.6 ± 24.5 | 61.8 ± 21.7 | 55.7 ± 20.5 | 53.5 ± 18.1 | 53.3 ± 18.5 | 22.1 ± 25.5 | 0.86 ± 0.26 |
| GA | 96 | 68.6 ± 25.2 | 63.9 ± 23.6 | 58.4 ± 22.6 | 54.3 ± 21.2 | 54.8 ± 19.6 | 24.0 ± 20.6 | 0.84 ± 0.25 | |
| AA | 5 | 51.4 ± 11.6 | 57.3 ± 16.7 | 51.9 ± 16.6 | 56.5 ± 16.4 | 52.4 ± 15.1 | -0.2 ± 8.7 | 1.01 ± 0.07 | |
| padd / pdom | - | - | 0.8 / 0.5 | 0.6 / 0.5 | 0.3 / 0.2 | 0.8 / 0.8 | 0.4 / 0.4 | 0.5 / 1.0 | 0.5 / 0.8 |
| rs9934336 | GG | 203 | 66.2 ± 24.4 | 62.4 ± 22.4 | 56.4 ± 20.5 | 54.2 ± 18.4 | 54.4 ± 18.6 | 21.8 ± 22.7 | 0.86 ± 0.25 |
| GA | 155 | 66.1 ± 25.2 | 61.9 ± 22.3 | 56.2 ± 22.2 | 52.6 ± 19.7 | 52.8 ± 18.9 | 23.3 ± 26.1 | 0.85 ± 0.26 | |
| AA | 17 | 66.1 ± 21.9 | 63.2 ± 17.6 | 57.1 ± 15.6 | 58.7 ± 15.6 | 51.8 ± 17.6 | 18.3 ± 27.1 | 0.82 ± 0.32 | |
| padd / pdom | - | - | 0.9 / 1.0 | 0.8 / 1.0 | 1.0 / 0.7 | 0.9 / 0.4 | 0.4 / 0.3 | 0.8 / 0.5 | 0.2 / 0.2 |
Glucagon concentrations are shown as unadjusted raw data (means ± SD). Prior to statistical analysis, non-normally distributed data were loge-transformed. Associations between SNP genotypes and glucagon concentrations were tested by multiple linear regression analysis (standard least squares method) with gender, age, BMI, and insulin sensitivity as covariates. All SNPs were analysed in the additive and dominant inheritance models (padd / pdom). AUCi–inverse area under the curve; OGTT–oral glucose tolerance test; SNP–single nucleotide polymorphism