Table 3.
Variables Related to the Presence of Lymphovascular Invasion
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
|
|
|
|||
| OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Depth of invasion | ||||
| Mucosa | 0.068 (0.032–0.145) | <0.001 | 0.023 (0.012–0.044) | <0.001 |
| Submucosa | 1 | 1 | ||
| Age | 1.031 (1.004–1.059) | 0.026 | 1.027 (1.005–1.050) | 0.017 |
| Country | ||||
| Japan | 2.413 (1.185–4.912) | 0.015 | 1.042 (0.612–1.775) | 0.880 |
| Korea | 1 | 1 | ||
| Sex | ||||
| Male | 0.736 (0.410–1.323) | 0.265 | - | - |
| Female | 1 | |||
| Cell type | ||||
| WD | 0.803 (0.323–1.994) | 0.636 | - | - |
| MD | 1.625 (0.692–3.817) | 0.265 | - | - |
| Poorly-cohesive* | 0.300 (0.114–1.793) | 0.051 | - | - |
| Mucinous | 1.869 (0.232–15.080) | 0.557 | - | - |
| PD | 1 | |||
| Size | 0.995 (0.982–1.009) | 0.494 | - | - |
| Location | ||||
| Lower | 1.197 (0.544–2.632) | 0.655 | - | - |
| Middle | 0.745 (0.358–1.548) | 0.430 | - | - |
| Upper | 1 | |||
| pN stage | ||||
| N0 | 0.185 (0.021–1.649) | 0.131 | - | - |
| N1 | 1.639 (0.163–16.462) | 0.675 | - | - |
| N2 | 0.575 (0.047–6.955) | 0.663 | - | - |
| N3 | 1 | |||
| Treatment | ||||
| Endoscopic resection | 0.000 (0) | 0.991 | - | - |
| Surgical resection | 1 | |||
OR, odds ratio; CI, confidence interval; WD, well differentiated; MD, moderately differentiated; PD, poorly differentiated.
*
Poorly cohesive carcinoma includes signet ring cell carcinoma.