Table IV. IGHG3 AA alleles deduced from genomic sequencing of the CH2 and CH3-CHS exons. As IGHG3 is encoded on chromosome 14 (14q 32.3), two IGHG3 alleles are expressed per sample.
| DNA samples | Nt substitutions and AA changes with reference to IGHG3*01 (X03604) |
Genomic IMGT IGHG3 alleles determined | IGHG3 AA alleles deduced | ||
|---|---|---|---|---|---|
| Nt IMGTa | AA IMGTa | AA EUb | |||
| AS50 | CH3 a250>g, a263>g, c267>a, c292>g, c300>t, a301>g | CH3 M84>V, K88>R, L89, Q98>E, N100, I101>V | CH3 M397V, K409R, L410 =, Q419E, N421 =, I422V | IGHG3*03 | IGHG3*03 |
| CH3 c237>g, g243>a, c292>g | CH3 N79>K, T81, Q98>E | CH3 N392K, T394 =, Q419E | IGHG3*13 | IGHG3*13 | |
| NP49 | CH3 a250>g, a263>g, c267>a, c292>g, c300>t, a301>g | CH3 M84>V, K88>R, L89, Q98>E, N100, I101>V | CH3 M397V, K409R, L410 =, Q419E, N421 =, I422V | IGHG3*03 | IGHG3*03 |
| - | - | - | IGHG3*01*04*05*10 | IGHG3*01*04*05*10 | |
| PA01 | - | - | - | IGHG3*01*04*05*10 | IGHG3*01*04*05*10 |
| - | - | - | IGHG3*01*04*05*10 | IGHG3*01*04*05*10 | |
| PA07 | CH3 c237>g, g243>a, c292>g | CH3 N79>K, T81, Q98>E | CH3 N392K, T394 =, Q419E | IGHG3*13 | IGHG3*13 |
| - | - | - | IGHG3*01*04*05*10 | IGHG3*01*04*05*10 | |
| PA09 | CH3 a250>g, a263>g, c267>a, c292>g, c300>t, a301>g | CH3 M84>V, K88>R, L89, Q98>E, N100, I101>V | CH3 M397V, K409R, L410 =, Q419E, N421 =, I422V | IGHG3*03 | IGHG3*03 |
| - | - | - | IGHG3*01*04*05*10 | IGHG3*01*04*05*10 | |
| PA16 | CH3 a250>g, a263>g, c267>a, c292>g, c300>t, a301>g | CH3 M84>V, K88>R, L89, Q98>E, N100, I101>V | CH3 M397V, K409R, L410 =, Q419E, N421 =, I422V | IGHG3*03 | IGHG3*03 |
| CH3 c237>g, g243>a, c292>g | CH3 N79>K, T81, Q98>E | CH3 N392K, T394 =, Q419E | IGHG3*13 | IGHG3*13 | |
| PA31 | CH3 a250>g, a263>g, c267>a, c292>g, c300>t, a301>g | CH3 M84>V, K88>R, L89, Q98>E, N100, I101>V | CH3 M397V, K409R, L410 =, Q419E, N421 =, I422V | IGHG3*03 | IGHG3*03 |
| CH3 g115>a, c237>g, a250>g, g344>a, t347>a | CH3 V39>M, N79>K, M84>V, R115>H, F116>Y | CH3 V379M, N392K, M397V, R435H, F436Y | IGHG3*17 | IGHG3*17 | |
| PA42 | - | - | - | IGHG3*01*04*05*10 | IGHG3*01*04*05*10 |
| - | - | - | IGHG3*01*04*05*10 | IGHG3*01*04*05*10 | |
| PA45 | - | - | - | IGHG3*01*04*05*10 | IGHG3*01*04*05*10 |
| - | - | - | IGHG3*01*04*05*10 | IGHG3*01*04*05*10 | |
| PA48 | CH3 a250>g, a263>g, c267>a, c292>g, c300>t, a301>g | CH3 M84>V, K88>R, L89, Q98>E, N100, I101>V | CH3 M397V, K409R, L410 =, Q419E, N421 =, I422V | IGHG3*03 | IGHG3*03 |
| CH3 a250>g, a263>g, c267>a, c292>g, c300>t, a301>g | CH3 M84>V, K88>R, L89, Q98>E, N100, I101>V | CH3 M397V, K409R, L410 =, Q419E, N421 =, I422V | IGHG3*03 | IGHG3*03 | |
a Nomenclature according to the IMGT unique numbering for C-DOMAIN (2, 25) and IMGT Allele alignment Homo sapiens IGHG3 (http://www.imgt.org/IMGTrepertoire/Proteins/alleles/index.php?species=Homo%20sapiens&group=IGHC&gene=IGHG3).
b Nomenclature adapted from Human Genome Variation Society (www.hgvs.org) and (29); amino acid (AA) EU numbering according to IMGT® www.imgt.org (23).