Figure 2.

Complete Remission of Disseminated Multiple Myeloma after One Intravenous Dose of Measles Virus MV-NIS

(A) CT rendering of plasmacytoma on the forehead of the patient showing the tumor protruding from the forehead and osteolytic lesion in the skull. (B) ¹⁸F-fludeoxyglucose positron emission tomography image of the glucose avid left frontal plasmacytoma in patient before virus treatment and the lower panel showing resolution of the tumor 7 weeks after MV-NIS treatment. (C) High-sensitivity eight-color plasma cell (PC) flow cytometry on bone marrow plasma cells before and after MV-NIS treatment, showing CD38- and CD138-positive, CD19-negative monoclonal plasma cells (λ-restricted) with hyperdiploid DNA content. In the bone marrow samples obtained 6 weeks after therapy (right panels), the abnormal PCs are not present (adapted from Russell et al.⁶⁷ Mayo Clinic Proceedings).