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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Neurol Clin. 2017 May;35(2):175–190. doi: 10.1016/j.ncl.2017.01.001

Fig. 1.

Fig. 1

Conformation-dependent antibodies label Ab in synaptic terminals. (A–D) Synapto- somes were dual labeled with synaptophysin and the monoclonal antibody M55 directed against prefibrillar oligomers: (A) M55; (B) synaptophysin (SYP); (C) overlay image with ar- rows indicating colocalization; (D) differential interference contrast (DIC) image. (E–H) Synaptosomes dual labeled with synaptophysin and the monoclonal antibody M116 directed against fibrillar oligomers: (E) M116; (F) synaptophysin (SYP); (G) overlay image with arrows indicating colocalization; (H) DIC image.