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GR binds to AREs in Dex and DEM co-treated cells. A, human gene loci of representative NRF2 target genes (NQO1, GCLM, and G6PD). Arrows, positions of AREs. B, ChIP assay with anti-GR antibodies using HepG2 cells treated with DEM and DEM + Dex. The average and S.D. (error bars) from triplicate reactions are shown. One-way ANOVA and Tukey's post hoc test were performed. *, p < 0.05; ***, p < 0.001; ns, nonsignificant.
