Table 4.

Association Between CRT-D Versus ICD and Outcomes Among All Patients and Among Subgroups When Stratified by PR Interval and QRS Characteristics

Group	Outcome	PR<230 ms				PR≥230 ms				Pinteraction
		Unadjusted		Adjusted by IPW		Unadjusted		Adjusted by IPW
		HR/sHR 95% CI	P Value	HR/sHR 95% CI	P Value	HR/sHR 95% CI	P Value	HR/sHR 95% CI	P Value
All patients	HF hospitalization or death	0.965 (0.918–1.014)	0.16	0.789 (0.734–0.849)	<0.0001	1.110 (1.008–1.222)	0.0347	1.010 (0.870–1.173)	0.90	0.0025
	Death	0.979 (0.923–1.039)	0.49	0.803 (0.738–0.875)	<0.0001	1.047 (0.934–1.173)	0.43	0.922 (0.782–1.087)	0.33	0.13
	HF hospitalization	0.969 (0.908–1.033)	0.33	0.794 (0.723–0.871)	<0.0001	1.093 (0.962–1.242)	0.17	1.033 (0.854–1.248)	0.74	0.01
Non LBBB	HF hospitalization or death	1.305 (1.219–1.396)	<0.0001	0.924 (0.826–1.034)	0.17	1.374 (1.195–1.579)	<0.0001	1.061 (0.832–1.352)	0.63	0.30
	Death	1.225 (1.129–1.330)	<0.0001	0.851 (0.750–0.966)	0.0128	1.237 (1.051–1.456)	0.0106	0.896 (0.686–1.171)	0.42	0.73
	HF hospitalization	1.352 (1.240–1.475)	<0.0001	1.035 (0.905–1.184)	0.62	1.344 (1.116–1.618)	0.0018	1.135 (0.854–1.510)	0.38	0.57
LBBB	HF hospitalization or death	0.907 (0.847–0.970)	0.0048	0.717 (0.652–0.788)	<0.0001	1.034 (0.898–1.192)	0.64	1.047 (0.835–1.313)	0.69	0.0015
	Death	0.965 (0.888–1.050)	0.41	0.764 (0.684–0.853)	<0.0001	1.019 (0.862–1.203)	0.83	0.968 (0.754–1.244)	0.80	0.08
	HF hospitalization	0.877 (0.805–0.956)	0.0028	0.685 (0.605–0.776)	<0.0001	1.007 (0.841–1.207)	0.94	1.022 (0.785–1.331)	0.87	0.0048

CI indicates confidence interval; CRT-D, cardiac resynchronization therapy with defibrillator; HF, heart failure; HR, hazard ratio; ICD, implantable cardioverter defibrillator; IPW, inverse probability weighted; LBBB, left bundle-branch block; and sHR, subdistribution hazard ratio.