Skip to main content
. 2017 Mar 3;16(3):508–517. doi: 10.1111/acel.12576

Figure 1.

Figure 1

Effects of CR on Srebp expression in the liver and white adipose tissue (WAT). (A–C) Copy numbers of Srebp‐1a (A), Srebp‐1c (B), and Srebp‐2 (C) mRNAs in liver tissue from wild‐type mice (WT) and knockout mice (KO) fed ad libitum (AL) and subjected to 30% caloric restriction (CR). (D–F) Copy numbers of Srebp‐1a (D), Srebp‐1c (E), and Srebp‐2 (F) mRNAs in WAT samples from WT and KO mice fed AL and subjected to 30% CR. Four groups of mice were further divided and given two treatments (fed or fasted). Accordingly, eight groups of mice (WTAL‐fed, WTAL‐fast, WTCR‐fed, WTCR‐fast, KOAL‐fed, KOAL‐fast, KOCR‐fed, KOCR‐fast) were euthanized at 8–10 months of age (n = 3–6 per group). Values shown in all panels are means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 vs. AL, †††P < 0.001 vs. WT, $$P < 0.01, $$$P < 0.001 vs. fed, analyzed by Tukey's test.