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APD prolongation of ventricular preparations under 0.05 μM dofetilide (n = 16) compared to population of models under 65% IKr block, corresponding to the effects of 0.5 μM dofetilide using IC50 and Hill coefficient determined by Kramer et al. (2013). Models displaying repolarization abnormalities (7/568 models) were excluded from the figure. Black dots are experimental data points, gray dots are outliers (>1.5 times interquartile range from the nearest inner quartile).
