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. 2017 May 5;10:126. doi: 10.3389/fnmol.2017.00126

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Copyright © 2017 Su, Shao, Zhao, Ren, Cai, Li, Bai, Chen, Xu, Wang, Cao and Zang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spinal nerve ligation-induced mechanical and thermal allodynia and the change in expression of Nav1.3 and miR-30b. (A,C) Responses of the ipsilateral paw to mechanical and thermal stimuli, ^∗∗∗P < 0.001 vs. sham, two-way ANOVA, n = 6 rats; (B,D) Responses of the contralateral paw to mechanical and thermal stimuli, P > 0.05 vs. sham, two-way ANOVA, n = 6 rats. (E–G) The decreased expression of miR-30b (E) and increased expression of Nav1.3 mRNA (F) and protein (G) in DRG neurons of SNL rats, ^∗∗P = 0.0013, ^∗P = 0.043, ^∗P = 0.045 vs. sham, two-tailed paired t-test, n = 3 rats. (H–J) The decreased expression of miR-30b (H) and increased expression of Nav1.3 mRNA (I) and protein (J) in spinal cord of SNL rats, ^∗∗P = 0.0015, ^∗P = 0.0488, ^∗P = 0.0471 vs. sham, two-tailed paired t-test, n = 3 rats. Data are shown as means ± SEM.